TABLE 1.
Summary of miRNAs in tendon tendinopathy.
| miRNA | Targets | Models | Cells | Biological functions | References |
| miRNA-499 | CUGBP2, MYB | Clinical samples of tendinopathy | Regulated cell proliferation, tenocyte apoptosis and differentiation | Cai et al., 2015 | |
| miR-205-5p | VEGFA | Rats BMSCs | involved in tendon-bone healing of RCT | Xu et al., 2019 | |
| miR-146a-5p, miR-193b-3p, etc. | JAK2/STAT3 and interconnecting pathways | Clinical Human biceps tendons | Linked to inflammation | Thankam et al., 2018 | |
| miR-31-5p, miR-195-5p, etc. | AMPK and TREM-1 signaling | Clinical Human rotator cuff tendon injuries | Associated with the pathogenesis of RCT injuries with fatty infiltration and inflammation | Thankam et al., 2019 | |
| miR-29b | TGF-β1/Smad3 | Achilles tendon injury rats | Inhibition of fibroblasts growth. | Chen et al., 2014 | |
| miR-21-5p | Smad7 | tendon adhesion in mice | Tenocytes and fibroblasts | Controlling the fibrotic healing response | Cui et al., 2019 |
| miR-337-3p | IRS1 and Nox4 | Rat TSPCs | Alleviating ectopic ossification in rat tendinopathy | Geng et al., 2020 | |
| miR-21-3p | p65 | HUMSC-Exos | tendon adhesion | Yao et al., 2020 | |
| miR-145-5p, miR-151a-3p, miR-382-5p, miR-199a-5p, miR-21-5p, miR-125a-5p, and miR-498 | COL1A2, COL3A1, MMP9 and MMP2 | Clinical human shoulder tendons | Associated with the integrity of tendon matrisome | Thankam et al., 2016 | |
| miR-608 | COL5A1 | HT1080 fibrosarcoma cells | Associated with the molecular basis of tendinopathy | Abrahams et al., 2013 | |
| miR-29a | IL-33/sST2 | Superficial digital flexor tendon of horses | Human tenocytes | Facilitating tissue remodeling in the tendon after injury | Millar et al., 2015; Watts et al., 2017 |
| miRNA-338, miRNA-381 | Scx | Untrained adult rats under a single session of mechanical loading | Tendon fibroblast | Regulating development of limb tendons | Mendias et al., 2012 |
| miR28-5p | p53 deacetylase sirtuin 3 | Primary human tenocytes | Prevention of bim RNA Degradation | Poulsen et al., 2014 | |
| miR-148a-3p | KLF6 | A co-culture system of tenocytes with ECs | Correlated with Tsp-4 levels and promoting angiogenesis | Ge et al., 2018 | |
| miR-210 | VEGF, FGF2 and COL 1 | Transected and repaired rats achilles tendons | via acceleration of angiogenesis | Usman et al., 2015 |