TABLE 2.
Summary of miRNAs in tenogenic differentiation (+).
| miRNA |
stem cells |
Targets | Tenogenic differentiation | References | |
| Cell type | Tissue origin | ||||
| miR-140-5p | TSPCs | Human tendons | Pin1 | (−) | Chen et al., 2015a |
| miR-29b-3p | MSCs and TSPCs | Human | TGF-β1 and COL1A1 | (−) | Lu et al., 2017 |
| miR-378a | TSPCs | Mice tail tendons | TGF-β2 | (−) | Liu et al., 2019 |
| miR124 | TSPCs | Human Anterior Cruciate Ligament | EGR1 | (−) | Wang et al., 2016 |
| let-7 | TSPCs | Human | HMGA2 | (−) | Sun et al., 2020 |
| miR-135a | TSPCs | Rat Achilles tendons | ROCK1 | (−) | Chen et al., 2015b |
| miR-217 | TSPCs | Human Achilles tendons | p16 | (+) | Han et al., 2017 |
| miR-218 | BMSCs | Rats | TOB1 | (+) | Gao et al., 2016 |
(+) and (−) represent promotion and inhibition, respectively.