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. 2021 Jul 1;24(7):102812. doi: 10.1016/j.isci.2021.102812

Figure 2.

Figure 2

Celsr3 cKO mice show impaired motor coordination and adaptive motor learning

(A) In rotarod tests, the falling latency was significantly shorter at each time point in Celsr3 cKO than in control mice. Compared to day 1, stay duration time increased at day 2 in controls, but not until day 5 in mutants. ∗, P< 0.05; ∗∗, P< 0.01, ANOVA post-hoc test; n = 8 mice in each group.

(B) In Catwalk tests, the swing speed and stand index of hindlimbs, and the maximal contact areas of hindpaws were significantly decreased in Celsr3 cKO compared to controls. ∗, P< 0.05; Student’s t-test; n = 8 mice in each group.

(C) In grid tests which evaluate walking coordination, the error ratio was significantly increased in Celsr3 cKO versus control mice. ∗∗, P< 0.01; Student’s t-test; n = 6 mice in each group.

(D and E) There was no significant difference between Celsr3 cKO and control mice in the open-field test (D) and the grid strength test (E). P> 0.05; Student’s t-test; n = 8 mice in each group.