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. 2021 Jul 1;24(7):102812. doi: 10.1016/j.isci.2021.102812

Figure 4.

Figure 4

Celsr3 cKO mice show decreased mEPSC frequency and PC dendritic atrophy

(A-C)Whole-cell recording of PCs in acute cerebellar slices. There is significant reduction of mEPSC frequency (A), but not amplitude (B) in Celsr3 cKO compared to control slices. ∗P< 0.05, Student’s t-test; 15 cells from 7 control mice and 17 cells from 6 mutant mice.

(C) Examples of recordings.

(D-F)Analysis of biocytin-injected PCs. There is a significant reduction of dendritic area (D), dendritic volume (E) and spine density (F) in Celsr3 cKO compared to control mice. Examples of PCs from control and Celsr3 cKO mice (F). ∗, P< 0.05; ∗∗, P< 0.01; Student’s t-test; n = 5 PCs in the control and n = 6 PCs in Celsr3 cKO.