Table 3.
CT evaluation
| Parameters | Patient- 1 (WJ-MSC treatment) |
Patient- 2 (WJ-MSC treatment) |
Patient- 3 (WJ-MSC treatment) |
Patient- 4 (WJ-MSC treatment) |
Patient- 5 (WJ-MSC treatment) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Base | Day 14 | Day 30 | Base | Day 14 | Day 30 | Base | Day 14 | Day 30 | Base | Day 14 | Day 30 | Base | Day 14 | Day 30 | |
| • CT parenchymal abnormalities: | |||||||||||||||
| a- GG0 | b | a ,c | a | a,b,d,e | a,c,d,e | a, c | a,c | a,c,d | a | b | a,b,e | a,e | a,b,d,g | a,b,d | NA |
| b- Consolidation | |||||||||||||||
| c- Reticular pattern | |||||||||||||||
| d- Mixed pattern | |||||||||||||||
| e- Linear opacities | |||||||||||||||
| f- Multifocal GGO of rounded morphology | |||||||||||||||
| g- Reverse halo sign or other findings of organizing pneumonia | |||||||||||||||
| • Type of GGO opacities: | |||||||||||||||
| a- Pure GGO | |||||||||||||||
| b- Crazy paving: GGO + intralobular lines | a | a | a | d | c,d | d | a | a,d | d | a | a,d | a,d | b | a | NA |
| c- Irregular lines and interfaces with architectural distortion + GGO | |||||||||||||||
| d- Streaky pattern | |||||||||||||||
| • Zonal involvement: | |||||||||||||||
| a- Right upper: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) | a (3) | a (2) | a (0) | a (3) | a (4) | a (3) | a (2) | a (3) | a (2) | a (4) | a (5) | a (1) | a (2) | a (5) | NA |
| b- Right middle: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) | b (3) | b (2) | b (0) | b (4) | b (2) | b (2) | b (2) | b (3) | b (1) | b (4) | b (5) | b (2) | b (3) | b (5) | |
| c- Right lower: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) | c (3) | c (1) | c (0) | c (4) | c (2) | c (2) | c (2) | c (3) | c (2) | c (4) | c (3) | c (2) | c (3) | c (5) | |
| d- Left upper: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) | d (3) | d (2) | d (1) | d (3) | d (4) | d (3) | d (2) | d (3) | d (2) | d (4) | d (5) | d (1) | d (3) | d (5) | |
| e- Left middle: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) | e (3) | e (1) | e (0) | e (4) | e (2) | e (2) | e (2) | e (3) | e (1) | e (4) | e (5) | e (2) | e (4) | e (5) | |
| f- Left lower: (0–5% = 1, 5–25% = 2, 26–50% = 3, 51–75% = 4, 76–100% = 5) | f (3) | f (2) | f (1) | f (4) | f (3) | f (2) | f (3) | f (3) | f (2) | f (4) | f (3) | f (2) | f (3) | f (5) | |
| • Total score of zonal involvement in both lungs: | 18 | 10 | 2 | 22 | 17 | 14 | 13 | 18 | 10 | 24 | 26 | 10 | 18 | 30 | NA |
|
• Cardiomegaly: (Yes/No) Severity (mild, moderate, severe) |
Yes (mild) | Yes (mild) | Yes (mild) | Yes (mild) | Yes (mild) | Yes (mild) | No | No | No | Yes (mild) | Yes (mild) | Yes (mild) | Yes (mild) | Yes (mild) | NA |
| a. Highly suggested | |||||||||||||||
| b. Indeterminate | a | b | d | a | b | c | a | a | b | a | b | b | a | a | NA |
| c. Inconsistent | |||||||||||||||
| d. None | |||||||||||||||