Table 1.
Development of caries and their severities on molars comparing wild-type mice with Amy1 knockout (KO) mice.
| Wild type | Amy1 KO | |
|---|---|---|
| Smooth surfaces | ||
| Total E | 9.35 (1.14) | 21.95 (2.53)* |
| Total Ds | 5.95 (0.87) | 16.65 (2.48)* |
| Total Dm | 4.10 (0.81) | 12.50 (1.96)* |
| Total Dx | 3.60 (0.83) | 11.60 (1.87)* |
| Buccal E | 2.00 (0.45) | 5.70 (0.73)* |
| Buccal Ds | 0.90 (0.34) | 2.85 (0.70)* |
| Buccal Dm | 0.45 (0.26) | 2.25 (0.55)* |
| Buccal Dx | 0.40 (0.26) | 1.85 (0.49)* |
| Lingual E | 3.80 (0.58) | 9.90 (1.45)* |
| Lingual Ds | 2.45 (0.54) | 8.20 (1.35)* |
| Lingual Dm | 2.15 (0.49) | 6.65 (1.12)* |
| Lingual Dx | 1.90 (0.46) | 6.30 (1.08)* |
| Proximal E | 3.55 (0.52) | 6.35 (0.65)* |
| Proximal Ds | 2.60 (0.41) | 5.60 (0.65)* |
| Proximal Dm | 1.50 (0.37) | 3.60 (0.57)* |
| Proximal Dx | 1.30 (0.38) | 3.45 (0.56)* |
| Sulcal surfaces | ||
| Total E | 9.85 (1.11) | 17.65 (1.86) |
| Total Ds | 6.95 (1.08) | 15.20 (1.71)* |
| Total Dm | 4.20 (0.78) | 10.95 (1.45)* |
| Total Dx | 1.60 (0.49) | 8.50 (1.33)* |
Values are the mean (SE) of Larson's modified Keyes' scores (Larson, 1981). 20 mice per group. Total smooth surface caries is the sum of buccal, lingual, and proximal caries, representing surfaces juxtaposed to the cheeks, tongue, and an adjacent tooth, respectively. Severity scores are: E (enamel affected), Ds (dentin exposed), Dm (3/4 of the dentin affected), and Dx (whole dentin affected). Comparisons are by ANOVA with Tukey–Kramer post-hoc test at 95% and 90% confidence.
*
P ≤ 0.05 vs. WT; P ≤ 0.10 vs. WT.