Table 2.
Univariable And Multivariable Analyses for preoperative and intraoperative variables of PHLF according to ISGLS criteria in the training cohort.
| Variables | Univariable logistic regression | Multivariable logistic regression | ||
|---|---|---|---|---|
| OR (95%CI) | P value | OR (95%CI) | P value | |
| Age, years | 1.018 (1.000-1.036) | 0.050 | ||
| Gender, (Female vs Male) | 0.494 (0.269-0.906) | 0.023 | ||
| Diabetes, (Yes vs No) | 1.158 (0.604-2.219) | 0.659 | ||
| Hypertension, (Yes vs No) | 1.468 (0.933-2.312) | 0.097 | ||
| HBsAg, (Yes vs No) | 1.360 (0.760-2.433) | 0.300 | ||
| Cirrhosis, (Yes vs No) | 2.839 (1.762-4.574) | <0.001 | 2.203 (1.070-3.824) | 0.030 |
| Neutrophil, 109/L | 0.921 (0.787-1.078) | 0.305 | ||
| Lymphocyte, 109/L | 0.291 (0.179-0.474) | <0.001 | ||
| Monocyte, 109/L | 1.596 (0.561-4.537) | 0.381 | ||
| Platelet, 109/L | 0.995 (0.992-0.998) | <0.001 | ||
| HB, g/L | 1.003 (0.992-1.014) | 0.629 | ||
| TBil, μmol/L | 1.075 (1.035-1.117) | <0.001 | ||
| DBil, μmol/L | 1.192 (1.097-1.296) | <0.001 | ||
| Alb, g/L | 0.909 (0.867-0.954) | <0.001 | ||
| ALT, U/L | 1.012 (1.004-1.020) | 0.002 | ||
| AST, U/L | 1.018 (1.010 1.025) | <0.001 | ||
| PT, s | 1.552 (1.299-1.853) | <0.001 | 1.886 (1.107-3.211) | 0.020 |
| INR | 1.761 (1.401-2.213) | <0.001 | ||
| Cre, μmol/L | 1.004 (0.994-1.014) | 0.460 | ||
| AFP, (≥400 vs<400 ng/ml) | 1.208 (0.796-1.832) | 0.374 | ||
| Tumor size, cm | 1.081 (1.030-1.135) | 0.002 | 1.107 (1.022-1.200) | 0.013 |
| Tumor number, (≥2 vs<2 ) | 1.677 (0.998-2.817) | 0.051 | ||
| ICG-R15 (%) | 1.169 (1.115-1.226) | <0.001 | 1.141 (1.070-1.216) | <0.001 |
| Blood loss, (≥400 vs<400 ml) | 2.870 (1.850-4.452) | <0.001 | 2.415 (1.306-4.468) | 0.005 |
| Operation time, min | 1.004 (1.001-1.007) | 0.006 | ||
| NLR | 1.194 (1.022-1.395) | 0.025 | ||
| PLR | 0.999 (0.996-1.002) | 0.594 | ||
| LMR | 0.725 (0.614-0.856) | <0.001 | ||
| ANRI | 1.064 (1.041-1.089) | <0.001 | ||
| APRI | 7.176 (4.212-12.226) | <0.001 | 4.652 (1.432-15.112) | 0.011 |
ICG-R15, indocyanine green retention rate at 15 min; AFP, α-fetoprotein level; HBsAg, hepatitis be antigen; HB, hemoglobin; ALB, albumin; TBIL, total bilirubin; DBIL, direct bilirubin; ALT, alanine transaminase; AST, aspartate transaminase; PT, prothrombin time; INR, international normalized ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; APRI, AST-to-platelet ratio index; ANRI, AST-to-neutrophil ratio index.