Table 8.
Comparison of acute-phase reactants of patients with M694V homozygous mutation versus other mutations.
| Parameters | M694V Homozygous(n = 10) Mean ± SD orMedian (min-max) | Other mutations(n = 45) Mean ± SD orMedian (min-max) | p |
|---|---|---|---|
| S100A12 (ng/mL) | 635 (245–1460) | 370 (30–1644) | 0.027* |
| SAA (mg/dL) | 25.24 (0.64–57.80) | 8.91 (0.06–138.00) | 0.050 |
| ESR (mm/h) | 51.50 (15.00–116.00) | 21.17 (3.00–62.00) | 0.001* |
| CRP (mg/L) | 33.06 (1.68–102.38) | 13.39 (0.13–157.47) | 0.081 |
| Fibrinogen (g/L) | 3.55 ± 1.03 | 2.65 ± 0.59 | 0.001* |
| ANC (103/mm3) | 7191.00 ± 4112.59 | 4401.70 ± 2296.73 | 0.004* |
| Lymp. count (103/mm3) | 2448.00 ± 925.09 | 2850.87 ± 951.00 | 0.228 |
| WBC count (103/mm3) | 11406.00 ± 4549.25 | 8194.68 ± 2711.58 | 0.004* |
*p < 0.05; Student t or Mann–Whitney U tests, SD: standard deviation; SAA: serum amyloid A, ESR: erythrocyte sedimentation rate; CRP: C-reactive protein, ANC: absolute neutrophil count; Lymp: lymphocyte; WBC: white blood cell.