Table: 5.

The non-compartmental and compartmental pharmacokinetic parameters for HPPH after i.v. bolus (4 mg/kg) administration to rat (n = 4)

		HPPH (4 mg/kg; i.v.)
Pharmacokinetic Parameters	Units	NC	1-C	2-C
C 0	ng/ml	7923.78 ± 141.63	--	---
AUC0-t	h*ng/ml	205135.9 ± 949.90	95553.25 ± 320.82	218314.01 ± 133.95
AUC0-α	h*ng/ml	217137.6 ± 976.53	---	---
AUMC	h*h*ng/ml	18466052 ± 725.74	2431570.01 ± 150.72	19334868.01 ± 250.45
MRT	h	85.09 ± 2.21	21.86 ± 10.81	88.29 ± 6.96
Kel	1/h	0.011 ± 0.01	---	---
T1/2	h	63.81 ± 3.75	---	---
T1/2α	h	---	---	1.07 ± 0.79
T1/2β	h	---	---	62.90 ± 6.62
CL	ml/h/kg	18.46 ± 0.86	49.10 ± 21.58	18.39 ± 1.14
Vd	ml/kg	1695.41 ± 151.67	---	---
V1	ml/kg	---	844.57 ± 166.05	597.02 ± 95.58
V2	ml/kg	---		1022.15 ± 139.99
K10	1/h	---	0.071 ± 0.032	0.039 ± 0.026
K12	1/h	---	---	0.901 ± 0.106
K21	1/h	---	---	0.301 ± 0.051
R2	---	---	0.8807 ± 0.04	0.9878 ± 0.01
AIC	---	---	373.77 ± 20.61	319.68 ± 10.21
SBC	---	---	375.95 ± 20.61	324.04 ± 10.21

NC: non-compartmental; 1-C: one-compartmental; 2-C: two-compartmental; AIC: Akaike information criterion; SBC: Schwarz-Bayes Criterion