Table 3. Risk of Cardiovascular Disease, Coronary Artery Disease, and All-Cause Mortality by CAC Score Category.
| CAC score (Agatston units) | HR (95% CI) | |||
|---|---|---|---|---|
| Unadjusted | Model 1a | Model 2b | Model 3c | |
| Cardiovascular diseased | ||||
| 0 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| 1-10 | 1.6 (1.4-2.0) | 1.2 (1.0-1.5)e | 1.2 (1.0-1.5)e | 1.1 (0.9-1.4) |
| 11-100 | 2.7 (2.4-3.2) | 1.8 (1.5-2.1) | 1.8 (1.5-2.1) | 1.8 (1.5-2.1) |
| 101-400 | 4.1 (3.4-4.9) | 2.2 (1.8-2.7) | 2.2 (1.8-2.7) | 2.1 (1.7-2.6) |
| >400 | 7.1 (5.9-8.6) | 3.6 (2.9-4.4) | 3.6 (3.0-4.4) | 3.4 (2.8-4.2) |
| Coronary artery diseasef | ||||
| 0 | 1 [Reference] | 1 [Reference] | 1 [Reference] | |
| 1-10 | 2.1 (1.4-3.0) | 1.7 (1.2-2.5) | 1.7 (1.2-2.5) | |
| 11-100 | 3.8 (2.8-5.0) | 2.9 (2.1-3.9) | 2.8 (2.1-3.9) | |
| 101-400 | 6.3 (4.5-8.8) | 4.3 (3.0-6.2) | 4.3 (3.0-6.1) | |
| >400 | 12.2 (8.8-16.8) | 7.9 (5.5-11.3) | 7.8 (5.5-11.2) | |
| All-cause mortality | ||||
| 0 | 1 [Reference] | 1 [Reference] | 1 [Reference] | |
| 1-10 | 1.6 (1.4-1.9) | 1.3 (1.1-1.6) | 1.4 (1.2-1.7) | |
| 11-100 | 1.8 (1.5-2.0) | 1.3 (1.1-1.5) | 1.3 (1.1-1.6) | |
| 101-400 | 2.9 (2.4-3.5) | 1.7 (1.4-2.1) | 1.8 (1.5-2.2) | |
| >400 | 5.1 (4.2-6.1) | 2.7 (2.3-3.3) | 2.8 (2.3-3.4) | |
Abbreviations: CAC, coronary artery calcium; CT, computed tomography; HR, hazard ratio.
Model 1: adjusted for age at time of CT scan and stratified by calendar year of CT scan. bModel 2: adjusted for age at time of CT scan, laterality, treated with anthracyclines and treated with trastuzumab, and stratified by calendar year of CT scan.
Model 3: adjusted for age at time of CT scan, laterality, treated with anthracyclines and treated with trastuzumab, and stratified by calendar year of CT scan; model included interaction between CAC and anthracyclines. Mortality model 1 and 2: age was transformed (natural spline with df = 3).
Cardiovascular disease included all cardiovascular disease hospitalizations and death (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] codes I00-199, lymphedema and varicose veins excluded [I88-89 and I83-86 respectively]).
95% CI lower limit >1.0.
Coronary artery disease included all coronary artery disease hospitalizations and death (ICD-10 codes I20-25, including angina pectoris and myocardial infarction).