Table 4. Risk of Cardiovascular Disease by CAC Score Category, Stratified by Treatmenta.
| CAC score (Agatston units) | Radiotherapy | Radiation boost | Anthracyclines | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Left-sided (n = 8223) | Right-sided (n = 7688) | Yes (n = 5182) | No (n = 5324) | Yes (n = 4333) | No (n = 11 582) | |||||||
| Incidence rate, per 1000 person-years | HR (95% CI) | Incidence rate, per 1000 person-years | HR (95% CI) | Incidence rate, per 1000 person-years | HR (95% CI) | Incidence rate, per 1000 person-years | HR (95% CI) | Incidence rate, per 1000 person-years | HR (95% CI) | Incidence rate, per 1000 person-years | HR (95% CI) | |
| 0 | 11.5 | 1 [Reference] | 9.9 | 1 [Reference] | 9.9 | 1 [Reference] | 12.6 | 1 [Reference] | 9.3 | 1 [Reference] | 11.2 | 1 [Reference] |
| 1-10 | 16.8 | 1.1 (0.9-1.4) | 18.0 | 1.4 (1.0-1.8) | 19.0 | 1.5 (0.9-2.4) | 23.6 | 1.2 (0.8-1.8) | 20.9 | 1.7 (1.1-2.7) | 16.7 | 1.1 (0.9-1.4) |
| 11-100 | 30.9 | 1.8 (1.4-2.2) | 27.9 | 1.8 (1.4-2.2) | 30.3 | 2.5 (1.7-3.7) | 35.3 | 1.9 (1.4-2.6) | 21.0 | 1.5 (1.0-2.2)b | 30.8 | 1.8 (1.5-2.1) |
| 101-400 | 41.4 | 2.0 (1.5-2.6) | 46.7 | 2.5 (1.9-3.3) | 41.6 | 2.3 (1.4-3.9) | 45.3 | 1.9 (1.3-2.8) | 53.0 | 3.1 (1.9-5.1) | 42.7 | 2.1 (1.7-2.6) |
| >400 | 89.4 | 3.8 (2.9-5.0) | 66.9 | 3.4 (2.5-4.5) | 100.2 | 6.1 (3.8-9.7) | 92.8 | 3.9 (2.7-5.4) | 110.1 | 5.8 (3.0-11.4) | 76.1 | 3.5 (2.8-4.3) |
Abbreviations: CAC, coronary artery calcium; HR, hazard ratio.
Cardiovascular disease included all cardiovascular disease hospitalizations and death (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] codes I00-199, lymphedema and varicose veins excluded [I88-89 and I83-86 respectively]). Models in patients who received left-sided or right-sided radiotherapy, and who were treated with and without anthracyclines were adjusted for age at time of CT scan and stratified by calendar year of CT scan. Models in patients who received radiotherapy with and without boost were adjusted for age at time of CT scan, laterality, treated with anthracyclines and treated with trastuzumab, and stratified by calendar year of CT scan; model included interaction between CAC and anthracyclines.
95% CI lower limit <1.0.