Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 2;15:660942. doi: 10.3389/fnins.2021.660942

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Manfready, Engen, Verhagen Metman, Sanzo, Goetz, Hall, Forsyth, Raeisi, Voigt and Keshavarzian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

PD patients demonstrated a diminished postprandial GLP-1 response compared to healthy matched control subjects, but there was no relationship with clinical characteristics. (A) Time course analysis of GLP-1 revealed a significant effect of time (p < 0.0001, F₍₂_.032_,59_.74₎ = 15.95), group (Control vs. PD, p = 0.01 F_(1,33₎ = 6.90), as well as an interaction (p = 0.001 F_(5,147₎ = 4.34). Area under the curve: control = 27,049 ± 4,548, PD = 18,818 ± 2,049, (B) Peak postprandial GLP-1 levels were significantly lower in PD subjects compared to controls (p = 0.02). There was no relationship between GLP-1 and clinical characteristics including: (C) finger tapping (p = 0.35, r = –0.25, r² = 0.06), (D) MDS-UPDRS (p = 0.31, r = 0.26, r² = 0.07), and (E) disease duration (p = 0.32, r = –0.25, r² = 0.06).