Table 1.
Significantly deregulated serum proteins in heart-irradiated mice.
| # | Protein accession | Protein ID | Protein description | Total unique peptides | Ratio 8/0 Gy | Ratio 16/0 Gy |
|---|---|---|---|---|---|---|
| 1 | P48410 | ABCD1 | ATP-binding cassette subfamily D member 1 | 20 | 0.712 | |
| 2 | P29699 | AHSG | Alpha-2-HS-glycoprotein | 12 | 0.989 | 1.043 |
| 3 | P05064 | ALDOA | Fructose-bisphosphate aldolase A | 48 | 0.435 | |
| 4 | Q91Y97 | ALDOB | Fructose-bisphosphate aldolase B | 5 | 0.476 | |
| 5 | P12246 | APCS | Serum amyloid P-component | 3 | 2.375 | |
| 6 | P09813 | APOA2 | Apolipoprotein A-II | 3 | 0.812 | |
| 7 | P06728 | APOA4 | Apolipoprotein A-IV | 28 | 0.891 | 0.993 |
| 8 | E9Q414 | APOB | Apolipoprotein B-100 | 16 | 1.301 | 1.271 |
| 9 | P34928 | APOC1 | Apolipoprotein C-I | 3 | 0.801 | |
| 10 | P08226 | APOE | Apolipoprotein E | 24 | 1.340 | |
| 11 | Q02105 | C1QC | Complement C1q subcomponent subunit C | 5 | 0.857 | |
| 12 | Q80X80 | C2CD2L | C2 domain-containing protein 2-like | 31 | 0.039 | |
| 13 | P01027 | C3 | Complement C3 | 99 | 1.153 | 0.895 |
| 14 | P01029 | C4B | Complement C4-B | 45 | 1.452 | 1.151 |
| 15 | P06684 | C5 | Complement C5 | 20 | 1.134 | |
| 16 | P55284 | CDH5 | Cadherin-5 | 27 | 1.468 | |
| 17 | P04186 | CFB | Complement factor B | 19 | 0.923 | |
| 18 | P06909 | CFH | Complement factor H | 45 | 1.234 | |
| 19 | Q61129 | CFI | Complement factor I | 8 | 0.870 | |
| 20 | P12960 | CNTN1 | Contactin-1 | 59 | 1.214 | |
| 21 | Q61147 | CP | Ceruloplasmin | 54 | 1.116 | |
| 22 | P09581 | CSF1R | Macrophage colony-stimulating factor 1 receptor | 5 | 1.178 | |
| 23 | P63037 | DNAJA1 | DnaJ homolog subfamily A member 1 | 26 | 0.258 | |
| 24 | Q61508 | ECM1 | Extracellular matrix protein 1 | 18 | 0.767 | 0.846 |
| 25 | Q01279 | EGFR | Epidermal growth factor receptor | 46 | 1.137 | |
| 26 | P19221 | F2 | Prothrombin | 26 | 0.972 | |
| 27 | Q9QXC1 | FETUB | Fetuin-B | 8 | 1.214 | |
| 28 | E9PV24 | FGA | Fibrinogen alpha chain | 30 | 1.435 | |
| 29 | P11276 | FN1 | Fibronectin | 145 | 1.008 | |
| 30 | P21614 | GC | Vitamin D-binding protein | 23 | 1.253 | |
| 31 | P13020 | GSN | Gelsolin | 44 | 0.902 | 0.987 |
| 32 | P01898 | H2-Q10 | H-2 class I, Q10 alpha chain | 11 | 1.212 | |
| 33 | P01942 | HBA | Hemoglobin subunit alpha | 18 | 1.467 | |
| 34 | P02088 | HBB-B1 | Hemoglobin subunit beta-1 | 19 | 1.460 | 1.309 |
| 35 | Q61646 | HP | Haptoglobin | 14 | 3.311 | |
| 36 | Q91X72 | HPX | Hemopexin | 24 | 1.328 | |
| 37 | P06330 | IG HEAVY C | Ig heavy chain V region AC38 205.12 | 3 | 1.116 | |
| 38 | P01864 | IGG | Ig gamma-2A chain C region secreted form | 4 | 1.310 | 1.849 |
| 39 | P01867 | IGH-3 | Ig gamma-2B chain C region | 9 | 1.821 | 2.659 |
| 40 | P01872 | IGHM | Ig mu chain C region | 16 | 1.585 | 1.696 |
| 41 | P01837 | IGK | Ig kappa chain C region | 5 | 1.242 | 1.514 |
| 42 | Q61702 | ITIH1 | Inter-alpha-trypsin inhibitor heavy chain H1 | 17 | 1.174 | |
| 43 | Q61703 | ITIH2 | Inter-alpha-trypsin inhibitor heavy chain H2 | 33 | 0.907 | |
| 44 | Q61704 | ITIH3 | Inter-alpha-trypsin inhibitor heavy chain H3 | 14 | 1.518 | 0.937 |
| 45 | A6X935 | ITIH4 | Inter alpha-trypsin inhibitor, heavy chain 4 | 23 | 1.632 | 0.993 |
| 46 | P04104 | KRT1 | Keratin, type II cytoskeletal 1 | 10 | 0.533 | |
| 47 | P08730 | KRT13 | Keratin, type I cytoskeletal 13 | 30 | 0.933 | |
| 48 | Q6NXH9 | KRT73 | Keratin, type II cytoskeletal 73 | 10 | 0.588 | |
| 49 | Q61233 | LCP1 | Plastin-2 | 44 | 0.672 | |
| 50 | P42703 | LIFR | Leukemia inhibitory factor receptor | 25 | 0.736 | 0.712 |
| 51 | Q80XG9 | LRRTM4 | Leucine-rich repeat transmembrane neuronal protein 4 | 9 | 0.751 | |
| 52 | P51885 | LUM | Lumican | 12 | 0.922 | |
| 53 | O09159 | MAN2B1 | Lysosomal alpha-mannosidase | 40 | 0.800 | |
| 54 | P04247 | MB | Myoglobin | 13 | 1.354 | |
| 55 | Q99KE1 | ME2 | NAD-dependent malic enzyme, mitochondrial | 37 | 0.751 | |
| 56 | P28665 | MUG1 | Murinoglobulin-1 | 63 | 0.877 | |
| 57 | P11589 | MUP2 | Major urinary protein 2 | 8 | 0.896 | |
| 58 | P97863 | NFIB | Nuclear factor 1 B-type | 21 | 0.358 | |
| 59 | O89084 | PDE4A | cAMP- 3′,5′-cyclic phosphodiesterase 4A | 21 | 0.718 | |
| 60 | P52480 | PKM | Pyruvate kinase PKM | 60 | 0.605 | |
| 61 | Q60963 | PLA2G7 | Platelet-activating factor acetylhydrolase | 18 | 1.110 | |
| 62 | P20918 | PLG | Plasminogen | 39 | 1.073 | |
| 63 | P55065 | PLTP | Phospholipid transfer protein | 12 | 1.102 | 1.420 |
| 64 | P52430 | PON1 | Serum paraoxonase/arylesterase 1 | 14 | 1.137 | |
| 65 | Q62009 | POSTN | Periostin | 39 | 1.183 | |
| 66 | Q61171 | PRDX2 | Peroxiredoxin-2 | 17 | 1.303 | 1.280 |
| 67 | Q61838 | PZP | Pregnancy zone protein | 70 | 1.052 | |
| 68 | P07758 | SERPINA1A | Alpha-1-antitrypsin 1-1 | 18 | 0.963 | |
| 69 | P22599 | SERPINA1B | Alpha-1-antitrypsin 1-2 | 6 | 0.824 | |
| 70 | Q00897 | SERPINA1D | Alpha-1-antitrypsin 1-4 | 8 | 0.835 | 0.832 |
| 71 | P07759 | SERPINA3K | Serine protease inhibitor A3K | 14 | 1.076 | |
| 72 | Q91WP6 | SERPINA3N | Serine protease inhibitor A3N | 17 | 1.503 | |
| 73 | P32261 | SERPINC1 | Antithrombin-III | 26 | 0.926 | |
| 74 | P49182 | SERPIND1 | Heparin cofactor 2 | 9 | 0.994 | |
| 75 | P97298 | SERPINF1 | Pigment epithelium-derived factor | 18 | 0.946 | |
| 76 | Q61247 | SERPINF2 | Alpha-2-antiplasmin | 6 | 0.841 | |
| 77 | P97290 | SERPING1 | Plasma protease C1 inhibitor | 12 | 1.149 | |
| 78 | P70441 | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor | 29 | 1.156 | |
| 79 | P35441 | THBS1 | Thrombospondin-1 | 63 | 1.233 | |
| 80 | Q9Z1T2 | THBS4 | Thrombospondin-4 | 23 | 1.220 | |
| 81 | P07309 | TTR | Transthyretin | 10 | 1.242 | |
| 82 | P29788 | VTN | Vitronectin | 10 | 1.168 | 1.042 |
The UniProt protein identifiers (ID), protein IPA code, full name, and fold changes (FC) of significantly differentially expressed proteins (q-value < 0.05) following local heart irradiation at 8 or 16 Gy are shown. Cells without any value mean that the protein did not pass the selection criteria in the proteomics analysis (q-value < 0.05, protein identification with at least two unique peptides). The shared proteins are in bold.