TABLE 3.
pQTL signals for the SCAD-associated RNA modification SNPs.
| SNP | Associated protein | Coding gene | Allele | BETA | StdErr | p-value pQTL | Source |
| rs12758270 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | ADAMTS4 | G | 0.1806 | 0.0693 | 9.29E-03 | Nat Commun 2017 |
| rs12758270 | Aromatic-L-amino-acid decarboxylase | DDC | G | −0.1880 | 0.0692 | 6.70E-03 | Nat Commun 2017 |
| rs12758270 | Beta-2-microglobulin | B2M | G | −0.1795 | 0.0640 | 5.16E-03 | Nat Commun 2017 |
| rs12758270 | C-C motif chemokine 20 | CCL20 | G | 0.1870 | 0.0694 | 7.14E-03 | Nat Commun 2017 |
| rs12758270 | Cysteine-rich secretory protein 3 | CRISP3 | G | −0.2458 | 0.0688 | 3.71E-04 | Nat Commun 2017 |
| rs12758270 | Extracellular matrix protein 1 | ECM1 | G | 0.3526 | 0.0680 | 2.66E-07 | Nat Commun 2017 |
| rs12758270 | Thyroid Stimulating Hormone | TSHB | G | −0.1808 | 0.0693 | 9.21E-03 | Nat Commun 2017 |
| rs28763967 | A disintegrin and metalloproteinase with thrombospondin motifs 15 | ADAMTS15 | T | 0.5301 | 0.1741 | 2.39E-03 | Nat Commun 2017 |
| rs28763967 | AMP Kinase (alpha1beta1gamma1) | PRKAA1 | T | 0.5433 | 0.1840 | 3.22E-03 | Nat Commun 2017 |
| rs28763967 | Baculoviral IAP repeat-containing protein 5 | BIRC5 | T | 0.5718 | 0.1832 | 1.85E-03 | Nat Commun 2017 |
| rs28763967 | C-C motif chemokine 21 | CCL21 | T | −0.4890 | 0.1783 | 6.23E-03 | Nat Commun 2017 |
| rs28763967 | Chromobox protein homolog 5 | CBX5 | T | 0.4764 | 0.1842 | 9.82E-03 | Nat Commun 2017 |
| rs28763967 | Granzyme H | GZMH | T | 0.4870 | 0.1844 | 8.40E-03 | Nat Commun 2017 |
| rs28763967 | Hepatocyte growth factor-like protein | MST1 | T | 0.4982 | 0.1840 | 6.88E-03 | Nat Commun 2017 |
| rs28763967 | Interleukin-17D | IL17D | T | 0.5379 | 0.1836 | 3.47E-03 | Nat Commun 2017 |
| rs28763967 | Ligand-dependent nuclear receptor corepressor-like protein | LCORL | T | 0.5652 | 0.1834 | 2.11E-03 | Nat Commun 2017 |
| rs28763967 | Phosphoglycerate kinase 1 | PGK1 | T | −0.5003 | 0.1811 | 5.85E-03 | Nat Commun 2017 |
| rs28763967 | Ras GTPase-activating protein 1 | RASA1 | T | 0.5732 | 0.1831 | 1.80E-03 | Nat Commun 2017 |
| rs28763967 | RNA-binding protein 39 | RBM39 | T | 0.4790 | 0.1839 | 9.33E-03 | Nat Commun 2017 |
| rs28763967 | Sialoadhesin | SIGLEC1 | T | 0.6622 | 0.1820 | 2.89E-04 | Nat Commun 2017 |
| rs11062 | Beta-2-microglobulin | B2M | A | −0.1252 | 0.0435 | 4.10E-03 | Nat Commun 2017 |
| rs11062 | C-C motif chemokine 14 | CCL14 | A | −0.1282 | 0.0458 | 5.24E-03 | Nat Commun 2017 |
| rs11062 | Elongation factor 1-beta | EEF1B2 | A | 0.1304 | 0.0467 | 5.33E-03 | Nat Commun 2017 |
| rs11062 | Fatty acid-binding protein, heart | FABP3 | A | −0.1178 | 0.0447 | 8.60E-03 | Nat Commun 2017 |
| rs11062 | Glycylpeptide N-tetradecanoyltransferase 1 | NMT1 | A | 0.1269 | 0.0466 | 6.62E-03 | Nat Commun 2017 |
| rs11062 | Granulysin | GNLY | A | −0.1295 | 0.0464 | 5.37E-03 | Nat Commun 2017 |
| rs11062 | Granzyme A | GZMA | A | −0.1219 | 0.0470 | 9.59E-03 | Nat Commun 2017 |
| rs11062 | Interleukin-4 | IL4 | A | 0.1859 | 0.0465 | 6.78E-05 | Nat Commun 2017 |
| rs11062 | Peptidyl-prolyl cis-trans isomerase E | PPIE | A | 0.1324 | 0.0466 | 4.57E-03 | Nat Commun 2017 |
| rs11062 | Platelet glycoprotein VI | GP6 | A | 0.1338 | 0.0468 | 4.30E-03 | Nat Commun 2017 |
| rs11062 | Receptor-type tyrosine-protein kinase FLT3 | FLT3 | A | 0.1226 | 0.0466 | 8.68E-03 | Nat Commun 2017 |
| rs11062 | Sialic acid-binding Ig-like lectin 14 | SIGLEC14 | A | −0.1431 | 0.0471 | 2.46E-03 | Nat Commun 2017 |
| rs11062 | S-phase kinase-associated protein 1 | SKP1 | A | 0.1320 | 0.0471 | 5.13E-03 | Nat Commun 2017 |
| rs11062 | Trefoil factor 3 | TFF3 | A | −0.1174 | 0.0445 | 8.53E-03 | Nat Commun 2017 |
| rs11062 | Tumor necrosis factor-inducible gene 6 protein | TNFAIP6 | A | −0.1278 | 0.0449 | 4.48E-03 | Nat Commun 2017 |
| rs11062 | Ubiquitin-conjugating enzyme E2 L3 | UBE2L3 | A | 0.1218 | 0.0467 | 9.31E-03 | Nat Commun 2017 |
| rs3818978 | C-C motif chemokine 14 | CCL14 | A | −0.0847 | 0.0256 | 9.38E-04 | Nature 2018 |
| rs580060 | Cystatin-F | CST7 | A | 0.0885 | 0.0253 | 4.69E-04 | Nature 2018 |
| rs1296748 | Retinoic acid receptor responder protein 1 | RARRES1 | T | −0.1087 | 0.0313 | 5.15E-04 | Nature 2018 |
| rs3818978 | C-C motif chemokine 22 | CCL2 | T | −0.1053 | 0.0408 | 9.86E-03 | PLoS Genet 2017 |
| rs3818978 | C-X-C motif chemokine 16 | CXCL16 | T | −0.1078 | 0.0408 | 8.24E-03 | PLoS Genet 2017 |
| rs3818978 | Dickkopf-related protein 1 | DKK1 | T | −0.1200 | 0.0408 | 3.27E-03 | PLoS Genet 2017 |
| rs3818978 | Heparin-binding EGF-like growth factor | HBEGF | T | −0.1162 | 0.0408 | 4.40E-03 | PLoS Genet 2017 |
| rs3818978 | Epidermal growth factor | EGF | T | −0.1255 | 0.0408 | 2.10E-03 | PLoS Genet 2017 |
pQTL, protein quantitative loci; SCAD, spontaneous coronary artery dissection; SNP, single-nucleotide polymorphism.