Fig. 3.

Comparative structural analysis of the receptor-binding domain (RBD) of the SARS-CoV-2. (a) Wild type spike protein of SARS-CoV-2, RBD is highlighted in yellow (b) RRDis map of wild type and manual mutant model of the RBD (c) RRDis map of energy mutant, evolutionary mutant, combine mutant (d) overlapping three-dimensional structures of wild type RBD (gold) and manual mutant model of RBD (cyan), (e) overlapping three-dimensional structures of different mutant models of RBD, energy mutant (pink), evolutionary mutant (gold), combine mutant (cyan), (f) correspondence analysis of different structural models (based on Dali Z-scores), (g) heatmap of different mutant models of the RBD. *Corresponding analysis is a multidimensional scaling method. It positions data with the most similar structural neighborhoods near each other.