a, Genome browser representation of ChIP-seq normalized reads for H2AK119ub, DNMT3A1 wild type and DNMT3A1 PWWP mutants in parental and sgRing1a/b mouse MSCs at chromosome 11: 95.98–96.04Mb. CGIs (green) and genes from the RefSeq database are annotated at the bottom. The shaded area indicates an H2AK119ub-enriched genomic region. b, Difference in ChIP-seq normalized reads of DNMT3A1 ΔPWWP between parental and sgRing1a/b mouse MSCs relative to that of H2AK119ub for 10-kb nonoverlapping bins genome-wide (n = 245,842). Pearson’s correlation coefficient is indicated. c, Difference in ChIP-seq normalized reads of DNMT3A1 ΔPWWP between parental and sgRing1a/b mouse MSCs relative to that of H2AK119ub for CGIs (n = 15,492). Pearson’s correlation coefficient is indicated.