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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Nat Genet. 2021 May 13;53(6):794–800. doi: 10.1038/s41588-021-00856-5

Fig. 2 |. PRC1-catalyzed H2AK119ub deposition is required for localization of DNMT3A to CGIs.

Fig. 2 |

a, Genome browser representation of ChIP-seq normalized reads for H2AK119ub, DNMT3A1 wild type and DNMT3A1 PWWP mutants in parental and sgRing1a/b mouse MSCs at chromosome 11: 95.98–96.04Mb. CGIs (green) and genes from the RefSeq database are annotated at the bottom. The shaded area indicates an H2AK119ub-enriched genomic region. b, Difference in ChIP-seq normalized reads of DNMT3A1 ΔPWWP between parental and sgRing1a/b mouse MSCs relative to that of H2AK119ub for 10-kb nonoverlapping bins genome-wide (n = 245,842). Pearson’s correlation coefficient is indicated. c, Difference in ChIP-seq normalized reads of DNMT3A1 ΔPWWP between parental and sgRing1a/b mouse MSCs relative to that of H2AK119ub for CGIs (n = 15,492). Pearson’s correlation coefficient is indicated.