Figure 4.

Man, 38 years at the time of the surgical excision of a pigmented lesion of the scapular area; at the baseline, the tumor shows a a relatively regular peripheral pigment network associated with slightly eccentric globules and a central bluish area (A) the tumor shows a progressive and relatively symmetric fading after 1 year (B), four years (C), and 6 years (D). The tumor discloses a “trizonal” histopathological pattern (E; hematoxylin–eosin, ×25), with an atypical junctional component, a scar-like dermal thickening (F; hematoxylin–eosin, ×100) and a very bland-appearing deep dermal component (G; hematoxylin–eosin, ×100); the proliferation rate (Ki67-positive dermal melanocytes, evaluated with a KI67/MART1 double stain) is very low (H; ×250). These histopathological features are consistent with the so-called “sclerosing nevus with pseudomelanomatus features”. Such a histopathological diagnosis is in keeping with the slowly progressive and relatively symmetrical involution of the tumor, as documented with dermoscopic digital monitoring. Clinical images provided by Dr. Luigi Ligrone, Salerno, I.