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. 2021 Feb 26;42(7):940–950. doi: 10.1093/carcin/bgab017

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Luteolin inhibits pSTAT3 and DPYD expression in the hamster pancreatic cancer model. Immunohistochemical findings of pSTAT3 in PanIN and PDAC (A) and nuclear pSTAT3 positivity of PanIN (Controls: n = 14, Lut 100 ppm: n = 13) and PDAC (Controls: n = 9, Lut 100 ppm: n = 3) in control and 100 ppm Lut treated animals (B). Expression of cytokine mRNA (Il6, Tgfβ, Tnfα, Il10) associated with the STAT3 pathway in hamster pancreas gastric lobe (n = 6 respectively, standardized by β2-microglobulin, Bmg) (C). DPYD expression detected in cytoplasm immunohistochemically (D) and its relative intensity in PanIN of 100 ppm Lut (n = 13) and controls (n = 14) (E). Graph of DPYD relative intensity and pSTAT3 nuclear positivity (Spearman rho = 0.41, P < 0.05) (F). Data are mean ± SD. *, ** P < 0.05, 0.01 as compared with controls.