Drug loading, release kinetics, and mechanical characterization
of DEX-loaded microPlates (DEX-μPLs). (a) DEX-μPL fabrication
yield and drug loading characterization; (b) DEX release profile from
μPLs under the sink condition (4 L, red line) and Weibull function
fitting (red line; 95% confidence band); (c) DEX release profile from
μPLs under confined conditions (500 μL; green line; 95%
confident band) and Weibull function fitting; (d) force-displacement
curve for a flat punch indentation experiment on μPLs (average
curve and standard deviation). In the inset, a schematic of the experimental
setup is provided; (e) mechanical damping of μPLs upon cyclic
loading (frequency 5 Hz) as a function of the force oscillation amplitude.
In the inset, a schematic of the testing routine highlights the phase
angle δ—dissipation parameter. Results are presented
as the average ± standard deviation (SD) (n =
3).