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. 2021 Jul 1;13(27):31379–31392. doi: 10.1021/acsami.1c02082

Figure 5.

Figure 5

Proinflammatory gene expression in a PTOA model mouse. (a) Schematic of the loading fixture used in the mechanical loading of mouse knee joints to induce PTOA; (b) mechanical loading regimen; (c) in vivo expression of IL-1β, TNF-α, IL-6, and MMP-13 measured by TaqMan qPCR (for each treatment groups n = 6, while for the healthy group n = 4). Statistical analysis via one-way ANOVA (GraphPad Prism 8), corrected for multiple comparisons by controlling the false discovery rate with a two-stage, step-up Benjamini–Krieger–Yekutieli method: *p < 0.05 and **p < 0.01, while no significant differences are indicated on the graphs as NS. A full list of p-values is provided in Table. S4.