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. 2021 Jul 2;9:662406. doi: 10.3389/fcell.2021.662406

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Copyright © 2021 Huang, Du, He, Yan and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic illustrating the triple functionality of CPMSN@125I-SD for stem cell therapy of brain ischemia. (B) Corresponding average intensities of CPMSN@125I-SD with various cobalt protoporphyrin IX (CoPP) concentrations in the NIR region. (C) Single-photon emission computed tomography imaging (SPECT)/CT images of ischemic mouse brain tissue on different days (0–7 days) after intracerebral injection of the labeled BMSCs (500,000 cells). (D) Cell death assessment for MSCs after treatment with different concentrations of CPMSN@125I-SD (0–100 μg ml^–1) and exposure to 100 μM H₂O₂ for 24 and 48 h. (E) Bar graph showing the quantification of the number of CD³¹⁺ cells (adapted from Yao et al., 2020). ^∗p < 0.05; ^∗∗p < 0.01.