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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Cell Rep. 2019 Jul 16;28(3):670–681.e8. doi: 10.1016/j.celrep.2019.06.014

Figure 7. The Gabra1–2 Mutation Rescues the Gabra2–1 Lethal Seizure Phenotype.

Figure 7.

(A) Genotyping for a Gabra1–2 homozygous (+/+) positive control, a Gabra2–1 homozygous (+/+) positive control, and two Gabra1–2/Gabra2–1 double heterozygous (+/−) animals. Primers to detect the α1–2 and the α2–1 mutation were used on both double heterozygotes.

(B) The Gabra1–2 mutation rescues the lethal seizure phenotype that leads to early mortality in Gabra2–1 heterozygotes. Data are shown as a percentage of Gabra2–1 and double heterozygous animals alive at a given time after birth (n = 20 mice/genotype).