Table 2.
Adjusted odds ratios (95% confidence intervals) for any metachronous CRA or advanced metachronous CRA compared to no CRA according to CRC family history characteristics
| Any metachronous adenoma |
Advanced metachronous adenoma |
|||
|---|---|---|---|---|
| Family history characteristic | CRA/total | Adjusted OR (95% CI)a | CRA/total | Adjusted OR (95% CI)a |
| No family history | 2777/5818 | 1.00 (Referent) | 710/5818 | 1.00 (Referent) |
| Any first-degree relative | 942/1879 | 1.14 (1.01–1.29) | 239/1879 | 1.15 (0.96–1.37) |
| Specific relativeb | ||||
| Mother | 318/616 | 1.27 (1.05–1.53) | 74/616 | 1.24 (0.94–1.65) |
| Father | 275/613 | 0.91 (0.75–1.10) | 65/613 | 0.92 (0.69–1.24) |
| Sibling | 360/643 | 1.34 (1.11–1.62) | 96/643 | 1.24 (0.95–1.62) |
| Number of relativesb | ||||
| 1 | 655/1357 | 1.07 (0.93–1.23) | 167/1357 | 1.14 (0.93–1.40) |
| 2+ | 117/212 | 1.39 (1.02–1.91) | 29/212 | 1.32 (0.83–2.07) |
| p-trend | 0.05 | 0.11 | ||
| Youngest age of sibling CRC diagnosis | ||||
| <54 years | 65/107 | 1.66 (1.08–2.56) | 15/107 | 1.24 (0.66–2.33) |
| 55–64 years | 66/116 | 1.34 (0.89–2.03) | 14/116 | 0.99 (0.53–1.85) |
| >65 years | 49/97 | 1.10 (0.70–1.72) | 11/97 | 0.71 (0.35–1.43) |
| p-trend | 0.008 | 0.79 | ||
a
Models adjusted for age, sex, history of polyps prior to baseline, number of colonoscopies during follow-up; and baseline adenoma location (distal, proximal, both) and baseline adenoma size
b
Data are missing or could not be definitively ascertained for specific relative (n = 7) and number of relatives (n = 310)