Table 3.
Adjusted odds ratios (95% confidence intervals) for proximal or distal metachronous CRA compared with no metachronous CRA
| Distal-only metachronous CRA |
Proximal-only metachronous CRA |
|||
|---|---|---|---|---|
| Family history characteristic | CRA/total | Adjusted OR (95% CI)a | CRA/total | Adjusted OR (95% CI)a |
| No family history | 728/3769 | 1.00 (Referent) | 1287/4328 | 1.00 (Referent) |
| Any first-degree relative | 213/1150 | 1.02 (0.86–1.23) | 442/1379 | 1.14 (0.99–1.31) |
| Specific relative | ||||
| Mother | 76/374 | 1.14 (0.87–1.51) | 148/446 | 1.25 (1.00–1.56) |
| Father | 68/406 | 0.89 (0.67–1.18) | 132/470 | 0.92 (0.74–1.16) |
| Sibling | 70/353 | 1.06 (0.80–1.42) | 170/453 | 1.41 (1.13–1.75) |
| Number of relatives | ||||
| 1 | 148/850 | 0.92 (0.75–1.14) | 308/1010 | 1.11 (0.94–1.30) |
| 2+ | 28/123 | 1.38 (0.88–2.15) | 56/151 | 1.43 (1.00–2.04) |
| p-trend | 0.83 | 0.05 | ||
| Youngest age of sibling CRC diagnosis | ||||
| <54 years | 15/57 | 1.53 (0.83–2.83) | 30/72 | 1.58 (0.96–2.60) |
| 54–64 years | 15/65 | 1.21 (0.67–2.21) | 31/81 | 1.26 (0.78–2.06) |
| >65 years | 7/55 | 0.63 (0.28–1.44) | 24/72 | 1.12 (0.67–1.87) |
| p-trend | 0.24 | 0.04 | ||
a
Models adjusted for age, sex, history of polyps prior to baseline, number of colonoscopies during follow-up; baseline adenoma location and baseline adenoma size