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. 2021 Jul 2;9:629270. doi: 10.3389/fbioe.2021.629270

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Copyright © 2021 Han, Lian, Wu, Qiao, Sun and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the experimental design. (A) Melt electrowritten (MEW) printer. The upper part is barreled. The needle is connected to the lower receiving plate to apply an electric field. The pore size of the scaffolds is controlled to 50, 100, 200, 300, and 400 μm, respectively. (B) New Zealand white rabbits were used to obtain bone marrow mesenchymal stem cells (BMSCs), chondrocytes, and tendon cells. (C) Implantation of different cells on the MEW scaffolds. (D) Cultured cells on a scaffold. (E) Induction of chondrogenic differentiation of BMSCs on scaffolds. (F) Fluorescence staining, microscopy, CCK-8, and other relevant tests were performed.