TABLE 2.

Subgroup analysis of the prognostic value of STATs in TCGA.

Gene	Variable	LGG	GBM	IDH-wild	IDH-mut
STAT1	HR	0.3411	0.9603	0.6173	0.5378
	95%CI	0.2366-0.4917	0.6608-1.396	0.4502-0.8464	0.3369-0.8586
	P-value	<0.0001	0.8320	0.0027	0.0094
STAT2	HR	0.5420	0.8141	0.7065	0.7648
	95%CI	0.3708-0.7923	0.5634-1.176	0.5186-0.9625	0.4685-1.249
	P-value	0.0016	0.2734	0.0276	0.2837
STAT3	HR	0.5147	0.7864	0.5498	0.6344
	95%CI	0.3609-0.7341	0.5441-1.137	0.4030-0.7500	0.4013-1.003
	P-value	0.0002	0.2009	0.0002	0.0514
STAT4	HR	0.7268	0.9123	1.052	1.206
	95%CI	0.5075-1.041	0.6303-1.320	0.7709-1.435	0.7608-1.913
	P-value	0.0816	0.6265	0.7508	0.4251
STAT5A	HR	0.4604	0.8298	0.6792	0.6681
	95%CI	0.3222-0.6580	0.5745-1.199	0.4991-0.9243	0.4183-1.067
	P-value	<0.0001	0.3200	0.0139	0.0913
STAT5B	HR	1.241	0.9398	1.191	0.7730
	95%CI	0.8696-1.770	0.6514-1.356	0.8726-1.625	0.4907-1.218
	P-value	0.2343	0.7398	0.2712	0.2667
STAT6	HR	0.6306	0.8302	0.7144	0.5877
	95%CI	0.4405-0.9029	0.5735-1.202	0.5210-0.9796	0.3716-0.9293
	P-value	0.0118	0.3240	0.0368	0.0230
The new model	HR	0.3723	0.9060	0.5307	0.5782
	95%CI	0.2593-0.5345	0.6275-1.308	0.3886-0.7247	0.3663-0.9128
	P-value	<0.0001	0.5983	<0.0001	0.0187

HR, Hazard Ratio; CI, confidence interval.