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. 2021 Jul 16;18:116. doi: 10.1186/s12984-021-00905-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Graphs of percent time in bradykinesia and Clinical Scales. a box (median and 75th percentile) and whiskers (90th percentile) of PTB and PTD levels of controls ( ) and PwP ( ) whose median BKS (mBKS) was either < 23 or ≥ 23 or median DKS (mDKS) was either < 5 or ≥ 5. The upper limit of PTB for controls (PTB = 30%) is shown as a green horizontal dotted line. The upper limit of PTD for controls (PTD = 20%) is shown as a green horizontal dotted line. b each participant’s PTB is plotted against their median BKS ( : PwP with median BKS ≥ 23, : PwP with median BKS < 23 and : control). The vertical red dotted line shows the target range for median BKS (mBKS < 26). The upper limit of PTB for controls (PTB = 30%) is shown as a green horizontal dotted line. The grey shaded region shows subjects whose median BKS were in target (< 26) but had excess PTB (≥ 30%). c a plot of each participant’s PTD plotted against their median DKS ( : PwP with median BKS ≥ 23, ( : PwP with median BKS < 23 and : control). The vertical red dotted line shows the target range for median DKS (mDKS < 7) and the horizontal green line shows PTD = 20%. The grey shaded region shows subjects whose median DKS were in target (< 7) but had excess PTD (≥ 20%). d PTD (Y axis) plotted against PTB (left axis) with each dot representing an individual PwP ( ) or Control ( ). The horizontal dotted green line represents the upper limit for PTD (20%) and the vertical dotted red line, the upper limit of PTB (30%) of controls. The small insert in the upper right represents the four quadrants formed by these lines and the numbers show the percentage of cases in each quadrant

Inline graphic — Graphs of percent time in bradykinesia and Clinical Scales. a box (median and 75th percentile) and whiskers (90th percentile) of PTB and PTD levels of controls ( ) and PwP ( ) whose median BKS (mBKS) was either < 23 or ≥ 23 or median DKS (mDKS) was either < 5 or ≥ 5. The upper limit of PTB for controls (PTB = 30%) is shown as a green horizontal dotted line. The upper limit of PTD for controls (PTD = 20%) is shown as a green horizontal dotted line. b each participant’s PTB is plotted against their median BKS ( : PwP with median BKS ≥ 23, : PwP with median BKS < 23 and : control). The vertical red dotted line shows the target range for median BKS (mBKS < 26). The upper limit of PTB for controls (PTB = 30%) is shown as a green horizontal dotted line. The grey shaded region shows subjects whose median BKS were in target (< 26) but had excess PTB (≥ 30%). c a plot of each participant’s PTD plotted against their median DKS ( : PwP with median BKS ≥ 23, ( : PwP with median BKS < 23 and : control). The vertical red dotted line shows the target range for median DKS (mDKS < 7) and the horizontal green line shows PTD = 20%. The grey shaded region shows subjects whose median DKS were in target (< 7) but had excess PTD (≥ 20%). d PTD (Y axis) plotted against PTB (left axis) with each dot representing an individual PwP ( ) or Control ( ). The horizontal dotted green line represents the upper limit for PTD (20%) and the vertical dotted red line, the upper limit of PTB (30%) of controls. The small insert in the upper right represents the four quadrants formed by these lines and the numbers show the percentage of cases in each quadrant