Table 2.

Mechanisms of NETs Formation in the Context of Cancer

Mouse model	Detected NETs marker	NETs Formation Mechanism	Reference
Lewis lung carcinoma; Breast carcinoma; CML	WB/IF: H3Cit; IF: DNA Plasma DNA Count; FACS: H3Cit+ Neutrophils	Cancer cell-derived G-CSF	[41]
Melonoma; Lewis lung carcinoma	WB/IF: H3Cit; IF: DNA	Cancer cell-derived G-CSF	[42]
Colorectal cancer liver metastasis	IF: MPO+ /H3Cit+/extracellular DNA+	Tumor-derived IL-8	[43]
Gall bladder cancer	IF: NE+ /H3Cit+/extracellular DNA+	Cancer cell-derived IL-8	[44]
Lewis lung carcinoma; Breast carcinoma; Colon carcinoma	IF: H3Cit+/extracellular DNA+	Cancer cell-derived CXCR1 and CXCR2 ligands	[45]
Lung metastasis of breast cancer	IF: MPO+ /H3Cit+/extracellular DNA+	Cancer cell-derived Cathepsin C	[46]
melanoma Pancreatic adenocarcinoma Lung adenocarcinoma	IF: MPO+ /H3Cit+/extracellular DNA+	Stroma-derived Amyloid β	[47]

WB Western Blot, IF Immunofluorescence, H3Cit citrullinated histone H3, MPO myeloperoxidase, NE neutrophil elastase, CXCR CXC Chemokine Receptor