Table 3:

Multivariable Cox model results for Overall survival (OSS) and Disease Specific Survival (DSS)

Variable		OS		DSS
	Unit	HR (95% CI)	p-value	HR (95% CI)	p-value
Classification	Both Bone invasion and EMI	1.66 (0.93, 2.97)	0.09	1.98 (1.03, 3.82)	0.04
	EMI alone	1.04 (0.62, 1.72)	0.89	0.93 (0.49, 1.73)	0.81
	Bone invasion alone	ref		ref
Gender	Female	1.60 (1.03, 2.49)	0.04	1.70 (1.00, 2.91)	0.05
	Male	ref		ref
N Classification ECS	N0	0.33 (0.17, 0.63)	<0.001	0.28 (0.12,0.65)	<0.001
	N+ no ECS	0.52 (0.30,0.92)	0.02	0.52 (0.27, 1.00)	0.05
	N+ ECS+	ref		ref
LVI	Yes	1.71 (1.05, 2.78)	0.03	2.74 (1.58, 4.74)	<0.001
	No	ref		ref
Margins	Positive	2.23 (1.14, 4.36)	0.02	1.49 (0.63, 3.52)	0.36
		ref		ref
Adjuvant Therapy	RT	0.42 (0.21,0.83)	0.01	0.38 (0.16, 0.94)	0.04
	ChemoRT	0.46 (0.22, 0.99)	0.05	0.46 (0.18, 1.20)	0.11
	None	ref		ref