TABLE 2.
Comparisons of acuity at presentation
| ALL (n = 10 359) | |||||||
|---|---|---|---|---|---|---|---|
| Overall | <1 year (n = 405) |
1–10 years (n = 9954) |
Crude PR (95% CI) |
p-Value | Adjusteda PR (95% CI) |
p-Value | |
| Acuity at presentation | |||||||
| Any ICU-level care requirement, n (%) | 469 (4.5) | 100 (24.7) | 369 (3.7) | 6.73 (5.28, 8.58) | <.001 | 6.64 (5.21, 8.57) | <.001 |
| Respiratory, n (%) | 213 (2.1) | 68 (16.8) | 145 (1.46) | 11.4 (8.18, 15.8) | <.001 | 11.4 (8.16, 15.9) | <.001 |
| Cardiac, n (%) | 184 (1.8) | 48 (11.9) | 136 (1.4) | 8.51 (6.41, 11.3) | <.001 | 8.48 (6.30, 11.4) | <.001 |
| Leukapheresis, n (%) | 156 (1.5) | 36 (8.9) | 120 (1.2) | 7.52 (4.94, 11.5) | <.001 | 7.20 (4.75, 10.9) | <.001 |
| Renal, n (%) | 105 (1.0) | 12 (3.0) | 93 (0.9) | 3.51 (1.85, 6.65) | <.001 | 3.38 (1.74, 6.56) | <.001 |
| Neurologic, n (%) | 2 (0.02) | 0 | 2 (0.02) | ne | |||
| Multisystem ICU requirement, n (%) | 156 (1.5) | 48 (11.9) | 108 (1.1) | 10.8 (7.36, 15.7) | <.001 | 10.5 (7.27, 15.3) | <.001 |
| AML (n = 871) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Overall | <1 year (n = 189) |
1–10 years (n = 682) |
Crude PR (95% CI) |
p-Value | Adjusteda PR (95% CI) |
p-Value | Adjustedb PR (95% CI) |
p | |
| Acuity at presentation | |||||||||
| Any ICU-level care requirement, n (%) | 84 (9.6) | 31 (16.4) | 53 (7.8) | 2.07 (1.40, 3.09) | <.001 | 1.96 (1.30, 2.97) | .001 | 1.86 (1.30, 2.67) | <0.001 |
| Respiratory, n (%) | 54 (6.2) | 23 (12.2) | 31 (4.6) | 2.67 (1.69, 4.20) | <.001 | 2.46 (1.63, 3.70) | <.001 | 1.73 (1.12, 2.67) | 0.0128 |
| Cardiac, n (%) | 30 (3.4) | 10 (5.3) | 20 (2.9) | 1.81 (0.93, 3.50) | .079 | 1.73 (0.91, 3.27) | .092 | 2.81 (1.53, 5.18) | <0.001 |
| Leukapheresis, n (%) | 33 (3.8) | 9 (4.8) | 24 (3.5) | 1.34 (0.66, 2.74) | .407 | 1.07 (0.46, 2.47) | .879 | 2.53 (1.13, 5.66) | 0.0242 |
| Renal, n (%) | 6 (0.7) | 2 (1.1) | 4 (0.6) | 1.81 (0.38, 8.61) | .458 | 1.53 (0.37, 6.27) | .554 | 3.13 (0.79, 12.4) | 0.104 |
| Neurologic, n (%) | 1 (0.1) | 0 | 1 (0.2) | ne | ne | ||||
| Multisystem ICU requirement, n (%) | 31 (3.6) | 11 (5.8) | 20 (2.9) | 1.98 (1.07, 3.69) | .030 | 1.70 (0.95, 3.02) | .074 | 2.60 (1.29, 5.23) | 0.007 |
Abbreviations: ALL, acute lymphoid leukemia; AML, acute myeloid leukemia; ICU, intensive care unit.
a
p-Value for the comparison of demographic distributions by age group (infant vs. noninfant) separately for ALL and AML.
b
p-Value for the comparison of demographic distributions among infants by disease group (i.e., ALL vs. AML) adjusted for gender, race, and ethnicity.