TABLE 4.
Comparisons of the prevalence (%) of utilization of specific resources during induction
| ALL (n = 10 359) | AML (n = 871) | Infant ALL vs. Infant AMLAdjustedc PR (95% CI) |
|||||
|---|---|---|---|---|---|---|---|
| <1 year (n = 405) |
1–10 years (n = 9954) |
Adjusteda PR (95% CI) |
<1 year (n = 189) |
1–10 years (n = 682) |
Adjustedb PR (95% CI) |
||
| Complete blood count | 91.9 | 94.7 | 0.97 (0.94, 1.00) | 99.8 | 99.7 | 1.00 (0.99, 1.00) | 0.96 (0.94, 1.00) |
| Blood culture | 78.4 | 66.2 | 1.18 (1.11, 1.27) | 23.3 | 25.3 | 0.92 (0.75, 1.12) | 2.98 (2.05, 4.32) |
| Antibiotics | 95.5 | 82.5 | 1.16 (1.13, 1.19) | 98.9 | 98.6 | 1.00 (0.98, 1.02) | 0.97 (0.80, 1.17) |
| Antifungals | 79.3 | 22.5 | 3.52 (2.83, 4.39) | 93.9 | 93.2 | 1.01 (0.97, 1.05) | 0.84 (0.78, 0.89) |
| Antivirals | 10.9 | 5.8 | 1.90 (1.43, 2.52) | 4.4 | 17.1 | 0.26 (0.13, 0.50) | 2.20 (0.96, 5.03) |
| Blood products | 89.8 | 82.6 | 1.09 (1.04, 1.14) | 97.9 | 99.9 | 0.98 (0.94, 1.01) | 0.94 (0.85, 1.03) |
| GCSF | 48.9 | 1.8 | 26.7 (20.4, 35.0) | 7.40 | 9.70 | 0.98 (0.35, 2.74) | 6.35 (3.57, 11.3) |
| Non-opioid analgesics | 82.7 | 75.4 | 1.10 (105, 1.15) | 82.1 | 85.8 | 0.96 (0.90, 1.02) | 0.97 (0.89, 1.05) |
| Opioid analgesics | 97.0 | 91.5 | 1.06 (1.04, 1.08) | 92.5 | 87.9 | 1.05 (1.00, 1.11) | 1.04 (0.98, 1.11) |
| Antiemetics | 99.5 | 93.9 | 1.05 (1.04, 1.08) | 99.4 | 99.9 | 1.00 (0.98, 1.01) | 1.01 (0.93, 1.09) |
| Total parenteral nutrition | 33.5 | 9.3 | 3.61 (2.72, 4.79) | 37.9 | 39.5 | 0.96 (0.75, 1.23) | 0.83 (0.65, 1.06) |
| Antihypertensives | 27.6 | 26.3 | 1.05 (0.90, 1.22) | 29.8 | 33.6 | 0.89 (0.55, 1.43) | 0.97 (0.80, 1.17) |
| Diuretics | 58.2 | 32.7 | 1.78 (1.57, 2.03) | 68.8 | 46.2 | 1.49 (1.23, 1.80) | 0.96 (0.83, 1.12) |
| Vasopressors | 35.9 | 26.0 | 1.38 (1.18, 1.62) | 26.7 | 26.3 | 1.02 (0.73, 1.42) | 1.29 (0.96, 1.74) |
| Supplemental oxygen | 56.9 | 37.1 | 1.53 (1.37, 1.72) | 42.9 | 42.6 | 1.01 (0.80, 1.26) | 1.52 (1.19, 1.93) |
| Ventilation | 29.5 | 6.2 | 5.15 (3.50, 7.59) | 28.0 | 22.7 | 1.23 (0.88, 1.72) | 0.96 (0.78, 1.19) |
| ECMO | 0.2 | 0.04 | 4.90 (0.37, 65.1) | 0.5 | 0.6 | 0.93 (0.10, 8.49) | 0.47 (0.03, 7.42) |
| Dialysis | 2.10 | 3.10 | 0.66 (0.43, 1.03) | 2.3 | 2.2 | 1.05 (0.38, 2.89) | 0.80 (0.33, 1.93) |
Abbreviations: ALL, acute lymphoid leukemia; AML, acute myeloid leukemia; ECMO, extracorporeal membrane oxygenation; GCSF, granulocyte colony-stimulating factor.
a
Prevalence ratio comparing resource use among infants with ALL versus noninfants aged 1–10 years with ALL; adjusted for race, ethnicity, and acuity at presentation.
b
Prevalence ratio comparing resource use among infants with AML versus noninfants aged 1–10 years with AML; adjusted for race, ethnicity, and acuity at presentation.
c
Prevalence ratio comparing resource use among infants with ALL versus infants with AML; adjusted for race, ethnicity, and acuity at presentation.