Table 4.

Associations of CVD risk score trajectories with incident hard CVD (n = 2619)

Events	Events/ n at risk (%)	Model 1*		Model 2†		Model 3‡
		HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Low-Low	70/2004 (3.5)	1.00 (Reference)	-	1.00 (Reference)	–	1.00 (Reference)	–
Medium-Medium	63/458 (13.8)	4.51 (3.21–6.34)	< 0.001	2.40 (1.46–3.97)	0.001	2.14 (1.19–3.85)	0.011
High-High	13/60 (21.7)	8.58 (4.74–15.53)	< 0.001	3.46 (1.56–7.70)	0.002	3.14 (1.15–8.52)	0.025

CVD cardiovascular disease, HR hazard ratio, CI confidence interval

^*Unadjusted model

^† Model 2 was adjusted for age at examination cycle four

^‡ Model 3 was adjusted for age, education, and family history CVD at examination cycle four