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. 2021 Jul 16;43:29. doi: 10.1186/s41021-021-00200-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 16 — HAA and HONH-HAA cytotoxicity and DNA adduct formation in LNCaP cells. a and b LNCaP cells were treated with DMSO (0.1%), HAAs, and HONH-HAAs (0.1 μM – 10 μM), for 24 h. Cell viability was evaluated by the MTS assay. c and d HAA and HONH-HAA DNA adduct formation in LNCaP cells after 24 h were measured by UPLC-ESI/MS³. Data are representative of at least three different experiment and are expressed as mean ± SD. ND: not detected. Ctrl: control