Table 2.
HAA mutagenicity in rodentsa
HAA | Animal | Strain | Target organ | Mutations | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
H-ras | Ki-ras | N-ras | p53 | APC | β-Cat | MM | LacI | LacZ | ||||
PhIP | Rat | F344 | Colon | 0/9 | 0/9 | 0/9 | 0/9 | 4/8 | 4/7 | 7/8 | ||
Big Blue | Colon mucosa | 227/227 | ||||||||||
Mammary gland | 149/149 | |||||||||||
Mouse | CDF1 | Lymphoid tissue | ||||||||||
Big Blue | Colon mucosa | 115/115 | 40/40 | |||||||||
MeIOx | Rat | F344 | Zymbal gland | 2/6 | ||||||||
MeIQ | Rat | F344 | Zymbal gland | 11/14 | ||||||||
IQ | Rat | F344 | Colon | 0/11 | 0/11 | 0/11 | 0/11 | 2/13 | 5/5 | |||
Zymbal gland | 4/7, 5/9 | 3/9 | 4/15 | |||||||||
Mouse | CDF1 | Liver | 7/34 | |||||||||
lung | 49/54 | |||||||||||
Glu-P-1 | Rat | F344 | Colon | 0/7 | 1/7 | 0/6 | 0/7 |