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. 2021 Jul 16;43:29. doi: 10.1186/s41021-021-00200-7

Table 2.

HAA mutagenicity in rodentsa

HAA Animal Strain Target organ Mutations
H-ras Ki-ras N-ras p53 APC β-Cat MM LacI LacZ
PhIP Rat F344 Colon 0/9 0/9 0/9 0/9 4/8 4/7 7/8
Big Blue Colon mucosa 227/227
Mammary gland 149/149
Mouse CDF1 Lymphoid tissue
Big Blue Colon mucosa 115/115 40/40
MeIOx Rat F344 Zymbal gland 2/6
MeIQ Rat F344 Zymbal gland 11/14
IQ Rat F344 Colon 0/11 0/11 0/11 0/11 2/13 5/5
Zymbal gland 4/7, 5/9 3/9 4/15
Mouse CDF1 Liver 7/34
lung 49/54
Glu-P-1 Rat F344 Colon 0/7 1/7 0/6 0/7

areproduced with permission [2, 68]