Figure 5.

Enhanced motor recovery with atomoxetine or fluoxetine treatment in cylinder test.

(A, B) Following photothrombotic stroke mice treated with atomoxetine or fluoxetine exhibited dose-dependent improvement in affected forelimb motor function (n = 12 per group). Compared to vehicle-treated group, mice treated with 1 mg/kg atomoxetine (^aP < 0.001) or 10 mg/kg fluoxetine (^fP = 0.04) showed statistically significantly improved motor function on day 42 after stroke (two-way repeated measures analysis of variance followed by Dunnett’s multiple comparison). Values are expressed as mean ± standard error. Atomo 0.3: 0.3 mg/kg atomoxetine; Atomo 1.0: 1.0 mg/kg atomoxetine; Fluox 3.0: 3 mg/kg fluoxetine; Fluox 10.0: 10 mg/kg fluoxetine.