Additional Table 1.
Completed and recruiting clinical trials of stem cells therapy for CP
| Project identifier | Sample size | Age (yr) | Intervention model | Status | Phase | Type of stem cell | Infusion route | Start/complete date | Study location |
|---|---|---|---|---|---|---|---|---|---|
| NCT01404663 | 12 | 4-12 | Single group assignme nt | Completed | Phase 1 | Bone marrow derived CD133+ stem cell | Intrathecal | October, 2011 to May, 2012 | Iran |
| NCT01763255 | 8 | 4-12 | Parallel assignment | Completed | Phase 1 and 2 | Bone marrow derived CD133 cell | Intrathecal | April, 2012 to April, 2014 | Iran |
| NCT03123562 | 25 | 1-15 | Single group assignme nt | Completed | Phase 2 | Autologous bone marrow mononuclear cell | Intrathecal | April, 2014 to October, 2016 | Vietnam |
| NCT02574923 | 30 | 2-15 | Single group assignme nt | Completed | Phase 2 | Autologous bone marrow mononuclear cell | Intrathecal | November, 2015 to April, 2018 | Vietnam |
| NCT02569775 | 40 | 1-15 | Single group assignme nt | Completed | Phase 2 | Autologous bone marrow mononuclear cell | Intrathecal | April, 2014 to August, 2015 | Vietnam |
| NCT01019733 | 18 | 1-8 | Single group assignme nt | Completed | Not provided | Autologous bone marrow stem cell | Intrathecal | July, 2009 to January, 2011 | Mexico |
| NCT02983708 | 57 | 2-10 | Crossover assignment | Completed | Phase 1 and 2 | Autologous peripheral blood stem cell | Not provided | August, 2011 to September, 2014 | Korea |
| NCT01193660 | 105 | 10mon-10 | Parallel assignment | Completed | Not provided | Total nucleated cells from allogenic umbilical cord blood | Intravenous | May, 2010 to April, 2011 | Korea |
| NCT01639404 | 17 | 6 mon-20 | Single group assignme nt | Completed | Not provided | Total nucleated cells from allogenic umbilical cord blood | Intravenous/intraarteria l | July, 2012 to March, 2013 | Korea |
| NCT02025972 | 10 | Less than 15 | Single group assignme nt | Completed | Not provided | Total nucleated cells from allogenic umbilical cord blood | Not provided | December,2013 to November, 2015 | Korea |
| NCT01991145 | 92 | 10mon-6 | Parallel assignment | Completed | Not provided | Total nucleated cells from allogenic umbilical cord blood | Not provided | November,2013 to June, 2017 | Korea |
| NCT02236065 | 10 | 19-75 | Single group assignme nt | Completed | Not provided | Total nucleated cells from allogenic umbilical cord blood | Not provided | August, 2014 to July, 2016 | Korea |
| NCT01528436 | 37 | 6 mon-20 | Parallel assignment | Completed | Phase 2 | Total nucleated cells from allogenic umbilical cord blood umbilical cord blood | Intravenous/intraarteria l | February,2012 to July, 2012 | Korea |
| NCT03979898 | 1 | 3-12 | Single group assignme nt | Completed | Early phase 1 | Autologous adipose tissue derived mesenchym al stem cell | Not provided | June, 2017 to May, 2019 | Korea |
| NCT01988584 | 20 | 2-10 | Crossover assignment | Completed | Phase 2 | Umbilical cord blood stem cells/bone marrow stem cell | Not provided | November, 2013 to February, 2018 | USA |
| NCT02599207 | 15 | 1-6 | Parallel assignment | Completed | Phase 1 | Total nucleated cells from allogenic umbilical cord blood | Not provided | November, 2015 to July, 2018 | USA |
| NCT01147653 | 63 | 1-6 | Crossover assignment | Completed | Phase 2 | Total nucleated cells from allogenic umbilical cord blood | Not provided | June, 2010 to March, 2016 | USA |
| NCT01929434 | 300 | 1-14 | Parallel assignment | Completed | Phase 3 | Umbilical cord derived mesenchymal stem cell | Intrathecal | October, 2013 to December, 2016 | China |
| NCT01072370 | 40 | 1-12 | Crossover assignment | Recruiting | Phase 1 and 2 | Autologous cord blood stem cell | Intravenous | January, 2010 to July, 2019 | USA |
| NCT03005249 | 20 | 1-12 | Parallel assignment | Recruiting | Not provided | Neural stem cell | Not provided | December, 2016 to December, 2019 | China |
| NCT03791372 | 25 | 6 mon-10 | Parallel assignment | Recruiting | Phase 1 | Total nucleated cells from allogenic umbilical cord blood | Intravenous | October, 2017 to April, 2021 | China |
| NCT03826498 | 40 | 1-10 | Parallel assignment | Recruiting | Phase 2 | Allogenic umbilical cord blood mononuclear cell | Not provided | January, 2018 to January, 2021 | Russian |
| NCT04098029 | 90 | 1-12 | Parallel assignment | Recruiting | Phase 2 | Umbilical cord blood hematopoietic cell | Not provided | Sepember, 2019 to May, 2021 | Russian |
CP: Cerebral palsy.