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. 2021 Apr 5;13(593):eabf1906. doi: 10.1126/scitranslmed.abf1906

Fig. 7. Determination of serum concentrations of LY-CoV555 in a cynomolgus monkey PK study and in rhesus macaques during SARS-CoV-2 infection.

Fig. 7

In the PK study, female cynomolgus monkeys received LY-CoV555 (5 mg/kg) as a single intravenous dose, and serum samples were collected through 672 hours after administration. Samples were analyzed using a human IgG ELISA or a ligand-capture LC-MS assay, which provided comparable results. Data points represent mean ± SD of determination from three animals. Cynomolgus monkey PK data are represented by green squares. In the rhesus macaque challenge experiments, animals (n = 3 or 4 per group) were administered LY-CoV555 (1, 2.5, 15, or 50 mg/kg) as a single intravenous dose, and serum samples were collected on study day −1 (predose) and days 0, 1, 3, and 6 (24, 48, 96, and 168 hours after intravenous dosing). Data points represent the mean ± SD for three or four animals. The blue arrow refers to viral challenge in rhesus macaque study on study day 0 (24 hours after intravenous administration of LY-CoV555).