Table 10.

Management of cognitive impairment in PSP/CBS.

1. Pharmacological management

a. Cholinesterase inhibitors such as donepezil

i. Use only for amnestic deficits

ii. Avoid in cases of severe postural instability

iii. Discontinue if no observed benefit

2. Non-pharmacological management

a. Caregiver and family education

b. Maintain a daily routine

i. Adapt previous activities to reduced abilities

ii. Emphasize enjoyable, rather than therapeutic, activities

iii. Minimize distractors

iv. Occupational therapy

1. Safety screening

a. Medication management

b. Financial risk

2. Access to stove, car, firearms

c. Compensatory technology

1. Daily planners

2. Mobile devices

d. Lifestyle modifications

1. Aerobic exercise

2. Heart-healthy diet

3. Adequate sleep and nutrition

4. Staying cognitively and socially engaged