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Src-1 regulates the expression of EMT-and proliferation-related genes in SP2-dependent manner. (a–d) The protein level determined by Western blot. Downregulation of SP2 alleviated Src-1-induced decrease of E-cad, bax, cytochrome c, and cleaved caspase3, and increase of N-cad, Vimentin, ZEB1, and bcl-2. Overexpression of SP2 abated the effects of Src-1 knockdown on the expression of E-cad, bax, cytochrome c, and cleaved caspase3, and increase of N-cad, Vimentin, ZEB1, and bcl-2.
