Figure 5.

(A) In vivo images of bioluminescent signals produced by MRSA Xen31(in photons/second/cm²/steradian) from the different mouse groups on the last day of the experiment; left column: with nine daily treatments; right column with four daily treatments. (B) Rifampicin and fucidin resistance develops during the treatment of mice. Rifampicin resistant cells (Rif-resistance) and fucidic acid resistant cells (Fucidic acid resistance) isolated from the wounds with strong bioluminescent signals were rechallenged and shown to be resistant to rifampicin (Rif) and fusidic acid (F.a.) but not to the MP1-rifampicin mixture. Wildtype MRSA Xen31 cells exposed to the MP1-ripamicin mixture, rifampicin and fusidic acid were sensitive to all three antimicrobials.