Fig. 1.

Nox2 limits LPS-induced systemic inflammation and hypotension. Wild-type (WT) and global Nox2-deficient (Global Nox2KO) mice were injected with LPS (10 mg/kg i.v.). (A, B) Plasma TNF-α and IL-6 levels (ELISA) after LPS injection; (C) lung neutrophil sequestration 6, 12, and 24 h after LPS treatment; (D) systolic blood pressure (BP) at baseline and 6 h after LPS injection; (E, F) plasma urea and aspartate aminotransferase (AST) 24 h after LPS injection. Graphs represent mean ± SEM (n = 3–5 per group). ∗P < 0.05 for indicated comparisons. 2-way ANOVA followed by Bonferroni post-test (C, D) or Kruskal–Wallis followed by Dunn's multiple comparison test (A, B, E, F).