Fig. 3.

Endothelial Nox2 reduces the extent of systemic inflammation and hypotension induced by LPS. (A) Schematic depicting the generation of bone marrow (BM) chimeric mice. BMT indicates bone marrow transplantation. Nox2 was deficient solely in endothelial cells (EC) (EC-Nox2KO) or BM cells (L-Nox2KO). KO-KO represents Nox2 deficiency in both cell types and FLOX-FLOX represents irradiated Nox2-replete mice. (B) Median ± range of clinical scores; (C, D) mean ± SEM of lung neutrophil sequestration and plasma tumor necrosis-(TNF)-α levels after LPS injection; (E) systolic blood pressure (BP) under baseline conditions and 6 h after LPS injection. ∗P < 0.05 for highlighted comparisons (n = 3 per group). 2-way ANOVA followed by Bonferroni post-test (B, E), or Kruskal–Wallis followed by Dunn's multiple comparison test (C, D).