Figure 3.

Networks for the 37 predicted causal eGenes. A, Gene ontology (GO) enrichment network of the 37 predicted causal eGenes. B, Protein-protein interaction (PPI) network of the CAD predicted causally associated eGenes in whole blood. The genes highlighted in green are targeted by approved inhibitors; genes in blue are potentially druggable by activators; and genes in purple are potentially druggable by inhibitors. C, Bar graph showing the enrichment in Reactome for genes of the PPI network (hypergeometric tests). VEGF indicates vascular endothelial growth factor.