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Manhattan plot for the genome-wide association study (GWAS) of gastrointestinal adverse events in COLCOT (Colchicine Cardiovascular Outcomes Trial) using Cox proportional hazards regression with 4 468 817 genetic variants of minor allele frequency ≥5% with 767 patients from the colchicine arm of COLCOT, controlling for age, sex, and principal components for genetic ancestry.
