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Cumulative incidence of coronary artery disease (CAD) in UK Biobank incident cases in group III. A, All of group III. B, Group III stratified into 4 subgroups according to age (45–54- and 55–69-y-old age ranges) and sex. Individuals are further stratified by polygenic risk score (PRS)–defined risk into the top 5% of PRS risk (red), the median 40% to 60% distribution of risk (blue), and the bottom 5% of risk distribution (green).
