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. 2021 Mar 2;14(2):e003304. doi: 10.1161/CIRCGEN.120.003304

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© 2021 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 3. — Model discrimination and net reclassification improvement for the integrated risk tool (IRT) compared with pooled cohort equations (PCE). A, Harrell’s C overall and across age-by-sex subgroups. Blue and red lines refer to IRT and PCE, respectively. Asterisks in x axis labels denote level of significance for the difference in Harrel C (***P<0.001). B, Net reclassification improvement (NRI) for the IRT compared with PCE alone across different age groups in men (blue) and women (red). The bars indicate the 95% CIs.