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. 2021 Jul 2;12:632482. doi: 10.3389/fimmu.2021.632482

Table 2.

Actinobacteria/Firmicutes phylum and inflammatory markers associated epitopes in PD were significantly correlated with pathways enriched in PD.

PD Group Pathways MEs Inflammatory biomarkers Proteins P value Correlation From
Actinobacteria phylum L.histidine degradation I LDLGITGPEGHVLSRPEEVEAEAV MONO DPYSL2 9.36E-05 0.452806 Homo sapiens
CGRPRAVYRKFGLCR NEUT.1, WBC RPSZ 0.020310 0.278889 Mycobacterium leprae
AGGVAVIKAGAATEVELKERKH MONO RML65 0.010781 0.305162 Mycobacterium tuberculosis
ADMLVRAWVRSYGVRATISN MONO.1, NEUT.1, WBC RMLB 0.035289 0.253884
L.proline biosynthesis II from arginine LDLGITGPEGHVLSRPEEVEAEAV MONO DPYSL2 0.00025 0.427394 Homo sapiens
NVDRTIRSVKRHMGSDWSIE NEUT.1, WBC DNAK 0.000259 0.426357 Mycobacterium leprae
AGGVAVIKAGAATEVELKERKH MONO RML65 2.69E-08 0.609702 Mycobacterium tuberculosis
CGRPRAVYRKFGLCR NEUT.1, WBC RPSZ 2.33E-07 0.575328
AGGVAVIKAGAATEVELKERKH MONO RML65 2.69E-08 0.609702
CGRPRAVYRKFGLCR NEUT.1, WBC RPSZ 2.33E-07 0.575328
ADMLVRAWVRSYGVRATISN MONO.1, NEUT.1, WBC RMLB 8.21E-07 0.553281
TEVELKERKHRIEDAVRNAK NEUT.1, WBC RML65 4.60E-05 0.470052
DAMRWFLMASPILRGGNLIV NEUT.1, WBC ILES 0.000266 0.425705
HSDDFQIILVDTPGLHRPRT NEUT.1 ERA 0.000819 0.393644
ERTRDRVRVDIHTARPGIVI NEUT.1, WBC RPSC 0.001324 0.378935
RYTTIQNWSNNVYNL NEUT.1, WBC RV1461 0.005517 0.330683
ADPVKVTRSALQNAASIAGL NEUT.1, WBC GROEL2 0.009855 0.30871
Firmicutes phylum Isopropanol biosynthesis AGGVAVIKAGAATEVELKERKH MONO RML65 0.00453 0.337799 Mycobacterium tuberculosis
Pyruvate fermentation to propanoate I LDLGITGPEGHVLSRPEEVEAEAV MONO DPYSL2 4.50E-05 0.265658 Homo sapiens
ADMLVRAWVRSYGVRATISN MONO.1, NEUT.1, WBC RMLB 5.42E-06 0.257598 Mycobacterium tuberculosis