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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Science. 2020 Jan 3;367(6473):96–100. doi: 10.1126/science.aax5217

Fig. 4. Order of evolutionary events leading to repression of the a-specific genes by Matα2.

Fig. 4.

The three-protein solution for repressing the haploid-specific genes remains in the W. anomalus clade, but in the S. cerevisiae lineage it was partitioned into a-specific gene regulation (which uses only two proteins, Mcm1 and Matα2) and repression of the haploid-specific genes (which requires Matα2 and Mata1). The three-protein intermediate explains how the necessary changes in the regulatory protein Matα2 could have been maintained for millions of years before being co-opted for the new circuit.