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. 2021 Jun 16;13(6):e15691. doi: 10.7759/cureus.15691

Table 2. Comparison of clinical and laboratory features between those with and without lupus hepatitis.

SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; low C3: low serum complement C3 (normal range: 0.9-1.8 g/L); low C4: low serum complement C4 (normal range: 0.1-0.4 g/L)

Parameter Lupus hepatitis, n=7, n (%) No lupus hepatitis, n=128, n (%) P-value OR (95% CI)
Female 7 (100) 123 (94.6) 1 0.9 (0.9-1)
Newly diagnosed 6 (85.7) 30 (23.6) 0.002 19.4 (2.2-167)
SLEDAI-2K score ≥10 3 (43) 64 (50) 1 0.75 (0.16-3.9)
Prednisolone use 6 (85.7) 67 (52.3) 0.12 5.4 (0.64-46)
Arthritis 5 (71.4) 86 (67.2) 1 0.9 (0.9-1)
Myositis 0 2 (1.6) 1 1 (1.01-1.09)
Malar rash 4 (57) 82 (64) 0.7 0.7 (0.16-3.5)
Alopecia 7 (100) 93 (73) 0.19 0.9 (0.8-1)
Oral ulcers 6 (87.5) 97 (76) 0.19 0.9 (0.8-1)
Vasculitis 1 (14.3) 24 (19) 1 0.7 (0.08-6.2)
Neuropsychiatric manifestations 0 15 (11.7) 1 1.06 (1.06-1.1)
Lupus nephritis 3 (43) 63 (49) 1 0.7 (0.16-3.5)
Serositis 1 (14.3) 7 (5.5) 0.3 2.8 (0.3-27)
Hematological involvement 4 (57) 61 (47.7) 0.7 1.4 (0.3-6.8)
Platelet count <100,000/mm3 2 (28.6) 16 (12.5) 0.23 2.8 (0.5-15.7)
Hemoglobin <10 g/dL 4 (57) 51 (40) 0.4 2 (0.4-9.3)
Low C3 4 (57) 60 (47) 0.7 1.5 (0.3-7)
Low C4 3 (43) 45 (35) 0.7 1.3 (0.3-6.4)
Serum albumin <3.5 g/dL 5 (71.5) 52 (40.6) 0.13 3.6 (0.7-19.5)
Hepatomegaly 0 2 (1.6) 0.7 1.05 (1.01-1.1)
Splenomegaly 0 3 (2.3) 1 1.05 (1.01-1.1)
Fatty liver 0 6 (4.7) 1 1 (1.01-1.1)