Table 2. Comparison of clinical and laboratory features between those with and without lupus hepatitis.
SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; low C3: low serum complement C3 (normal range: 0.9-1.8 g/L); low C4: low serum complement C4 (normal range: 0.1-0.4 g/L)
Parameter | Lupus hepatitis, n=7, n (%) | No lupus hepatitis, n=128, n (%) | P-value | OR (95% CI) |
Female | 7 (100) | 123 (94.6) | 1 | 0.9 (0.9-1) |
Newly diagnosed | 6 (85.7) | 30 (23.6) | 0.002 | 19.4 (2.2-167) |
SLEDAI-2K score ≥10 | 3 (43) | 64 (50) | 1 | 0.75 (0.16-3.9) |
Prednisolone use | 6 (85.7) | 67 (52.3) | 0.12 | 5.4 (0.64-46) |
Arthritis | 5 (71.4) | 86 (67.2) | 1 | 0.9 (0.9-1) |
Myositis | 0 | 2 (1.6) | 1 | 1 (1.01-1.09) |
Malar rash | 4 (57) | 82 (64) | 0.7 | 0.7 (0.16-3.5) |
Alopecia | 7 (100) | 93 (73) | 0.19 | 0.9 (0.8-1) |
Oral ulcers | 6 (87.5) | 97 (76) | 0.19 | 0.9 (0.8-1) |
Vasculitis | 1 (14.3) | 24 (19) | 1 | 0.7 (0.08-6.2) |
Neuropsychiatric manifestations | 0 | 15 (11.7) | 1 | 1.06 (1.06-1.1) |
Lupus nephritis | 3 (43) | 63 (49) | 1 | 0.7 (0.16-3.5) |
Serositis | 1 (14.3) | 7 (5.5) | 0.3 | 2.8 (0.3-27) |
Hematological involvement | 4 (57) | 61 (47.7) | 0.7 | 1.4 (0.3-6.8) |
Platelet count <100,000/mm3 | 2 (28.6) | 16 (12.5) | 0.23 | 2.8 (0.5-15.7) |
Hemoglobin <10 g/dL | 4 (57) | 51 (40) | 0.4 | 2 (0.4-9.3) |
Low C3 | 4 (57) | 60 (47) | 0.7 | 1.5 (0.3-7) |
Low C4 | 3 (43) | 45 (35) | 0.7 | 1.3 (0.3-6.4) |
Serum albumin <3.5 g/dL | 5 (71.5) | 52 (40.6) | 0.13 | 3.6 (0.7-19.5) |
Hepatomegaly | 0 | 2 (1.6) | 0.7 | 1.05 (1.01-1.1) |
Splenomegaly | 0 | 3 (2.3) | 1 | 1.05 (1.01-1.1) |
Fatty liver | 0 | 6 (4.7) | 1 | 1 (1.01-1.1) |