Table 4.

Binding affinities and interactions of top ten ligands against nsp15

Target	Cpd	Binding affinity (kcal/mol)	Hydrogen bonds	Other interactions
nsp15	15	− 8.6	Met243	Met243, Tyr262, Glu258, His362, Ala256
	4	− 8.5	None	Lys281, Glu285, Tyr262, Met243
	1	− 8.4	Gly254	Met243, Ala256, Glu258
	25	− 8.1	Phe265, Ser266	Lys281, Ser266, Ala256
	23	− 8	None	Glu258, Ala256, Gly263, Asp264, Phe265
	26	− 7.8	Glu285, Glu364	Ala256, Ser266, Met243, Lys281, Glu285
	12	− 7.7	Glu285	Ala256, Met243, Tyr262, Lys281
	14	− 7.7	Arg282	Glu285, Lys281, Phe265
	13	− 7.3	Gly263, Asp264	Ala256, His259, Asp264, Met243, Glu285
	17	− 7.3	Glu258	None